Autophagy: Chapter 13. Cell Surface Pathogen Receptor CD46 Induces Autophagy Book PDF, ePub eBook

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Book Descriptions:
CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products. CD46 is also recognized by several human pathogens that use this surface protein as an entry receptor. Cross-linking of CD46 leads to activation of different biological functions, including pathways involved in the regulation of innate and adaptive immunity. Work from the Rabourdin-Combe laboratory has described a new function for CD46 in the activation of macroautophagy. We showed that the engagement of CD46, using agonist antibody against CD46, induces formation of de novo autophagosomes that ultimately fuse with lysosomes. CD46-mediated autophagy is regulated by a scaffold protein named GOPC, which directly connects CD46 with the initiation complex of autophagy Beclin 1/PI3KC3. Interestingly, at least two CD46–binding pathogens, Group A streptococcus and measles virus, are able to induce autophagy through a CD46/GOPC pathway. CD46-mediated autophagy is clearly involved in the degradation of Group A streptococcus following their entry in cytosol. Thus, physical connection between CD46 and autophagy could confer on this receptor the potency to sense pathogens and initiate antimicrobial responses.

Autophagy: Chapter 13. Cell Surface Pathogen Receptor CD46 Induces Autophagy by Pierre-Emmanuel Joubert

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